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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13736 |
Interferon receptor inducer-1
|
IFNAR | Immunology/Inflammation |
Interferon receptor inducer-1 是一种干扰素(IFN)受体诱导剂,可用于干扰素诱导参与的紊乱性疾病的研究。 | |||
T12933 |
SM-276001
|
TLR; COX | Immunology/Inflammation; Neuroscience |
SM-276001 是可口服的干扰素诱导剂,是选择性TLR7激动剂,可以诱导抗肿瘤免疫反应。 | |||
T14687 |
Deucravacitinib
BMS-986165 |
Tyrosine Kinases; JAK; IFNAR; Interleukin | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂,用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活,可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域,IC50为1.0 nM。 | |||
T11630 |
IFN alpha-IFNAR-IN-1 hydrochloride
|
Others; IFNAR | Immunology/Inflammation; Others |
IFN alpha-IFNAR-IN-1 hydrochloride 是 IFN-α 和 IFNAR 相互作用的抑制剂。 IFN alpha-IFNAR-IN-1 hydrochloride 抑制 BM-pDCs 的 MVA 诱导的 IFN-α 反应,IC50 为 2-8 μM。 | |||
T7081 |
CCCP
Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙 |
Apoptosis; IκB/IKK; COX; Mitochondrial Metabolism; STING; IFNAR; Antibacterial | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB |
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂,线粒体质子载体解偶联剂。CCCP 抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。 | |||
T5317 |
Cridanimod
CMA,吖啶酮乙酸,XBIO-101,10-carboxymethyl-9-acridanone |
Progesterone Receptor; STING; IFNAR | Immunology/Inflammation; Others |
Cridanimod (10-carboxymethyl-9-acridanone, CMA) 是一种是小分子免疫调节剂和干扰素诱导剂,是一种孕酮受体激活剂,能够诱导 IFNα和IFNβ的表达,显著增加 PR 的表达。 | |||
T4403 |
AX-024 hydrochloride
AX-024 HCl |
IL Receptor; TNF; COX; IFNAR; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience |
AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂,可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂,可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导,具有低毒、高效和高选择性的特点。 | |||
T6273 |
Vadimezan
DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404 |
Influenza Virus; VDA; STING; IFNAR | Angiogenesis; Immunology/Inflammation; Microbiology/Virology |
Vadimezan (DMXAA) 是一种血管破坏剂,一种鼠 STING 激动剂,也是一种细胞因子如 I 型 IFN 的诱导剂。Vadimezan 具有抗肿瘤活性,可以诱导肿瘤中的血流快速停止,但不影响正常组织中的血流。 | |||
T22142 |
RO8191
RO4948191,CDM-3008 |
HCV Protease; HBV; JAK; IFNAR; STAT | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
RO8191 (CDM-3008) 是干扰素 (IFN) 受体激动剂。它直接与 IFNα/β 受体 2 结合,激活 IFN 刺激的基因表达和 JAK/STAT 磷酸化。它通过具有干扰素样活性发挥 cccDNA 调节剂作用,并具有抗 HBV 活性。 | |||
T80570 |
Dazukibart
|
IFNAR | Immunology/Inflammation |
Dazukibart为针对小鼠源性干扰素β1(IFNB1)设计的人源化IgG1κ单克隆抗体。 | |||
T73693 | Peginterferon beta-1a | ||
Peginterferon beta-1a (Peginterferon β-1a) 是一个聚乙二醇化干扰素 beta-1a 分子。Peginterferon beta-1a 诱导癌细胞凋亡并且在裸鼠模型中显示出抗肿瘤活性。Peginterferon beta-1a 可用于癌症和多发性硬化 (RMS) 的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3829 |
Ginsenoside F3
人参皂苷F3 |
Others; IFNAR; Interleukin | Immunology/Inflammation; Others |
Ginsenoside F3 是一种皂苷,提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达,有免疫增强的作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00831 |
IFN-beta Protein, Human, Recombinant (hFc)
IFNB,IFN-β,Interferon beta,interferon<... |
Human | HEK293 Cells |
IFN-beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.7 kDa and the accession number is A0A7R8GV38. | |||
TMPY-03145 |
IFN-beta Protein, Human, Recombinant
IFN-β,interferon, β1, fibroblast,IFNB,IFB,IFF,I... |
Human | CHO Cells |
IFN-beta Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 20 kDa and the accession number is P01574. | |||
TMPY-03467 |
IFN-beta Protein, Mouse, Recombinant
Ifb,IFN-β,interferon, beta 1, fibroblast,干... |
Mouse | HEK293 Cells |
IFN-beta Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.3 kDa and the accession number is P01575. | |||
TMPY-02647 |
IFNAR1 Protein, Human, Recombinant (His)
interferon (alpha, beta and omega) recepto... |
Human | HEK293 Cells |
IFNAR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.6 kDa and the accession number is P17181-1. | |||
TMPY-04799 |
IFNAR2 Protein, Human, Recombinant (His), Biotinylated
IFN-R,interferon (α, β and Ω) receptor 2,IFNABR, |
Human | HEK293 Cells |
IFNAR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P48551-1. | |||
TMPY-03828 |
IFN-beta Protein, Rhesus, Recombinant (mFc)
interferon, beta 1, fibroblast,干扰素,int... |
Rhesus | HEK293 Cells |
IFN-beta Protein, Rhesus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.4 kDa and the accession number is G7NFX1. | |||
TMPY-02456 |
IFN-beta Protein, Mouse, Recombinant (hFc)
Ifb,interferon, β1, fibroblast,IFN-β,干扰素,interf... |
Mouse | HEK293 Cells |
IFN-beta Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.7 kDa and the accession number is P01575. | |||
TMPY-04254 |
IFNAR1 Protein, Rhesus, Recombinant (His)
interferon (alpha, beta and omega) recepto... |
Rhesus | HEK293 Cells |
IFNAR1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.7 kDa and the accession number is H9Z8H4. | |||
TMPY-03829 |
IFNAR1 Protein, Rhesus, Recombinant (hFc)
interferon (α, β and Ω) receptor 1,interferon |
Rhesus | HEK293 Cells |
IFNAR1 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is H9Z8H4. | |||
TMPY-00139 |
IFNAR2 Protein, Cynomolgus, Recombinant (His)
interferon (α, β and Ω) receptor 2,interferon |
Cynomolgus | HEK293 Cells |
IFNAR2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is XP_005548871.1. | |||
TMPY-03927 |
IFNAR1 Protein, Rhesus, Recombinant
interferon (α, β and ω) receptor 1,interferon |
Rhesus | HEK293 Cells |
IFNAR1 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 48.3 kDa and the accession number is H9Z8H4. | |||
TMPY-01489 |
IFNAR1 Protein, Mouse, Recombinant (His)
Ifrc,Ifar,CD118,interferon (α, β and ω) receptor 1,... |
Mouse | HEK293 Cells |
IFNAR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is P33896. | |||
TMPY-01640 |
IFNAR2 Protein, Human, Recombinant (hFc)
interferon (α, β and ω) receptor 2,IFNABR,IFN-R, |
Human | HEK293 Cells |
IFNAR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.8 kDa and the accession number is P48551-1. | |||
TMPY-01642 |
IFNAR2 Protein, Human, Recombinant (His)
IFNARB,IFNABR,interferon (α, β and ω) receptor 2,IF... |
Human | HEK293 Cells |
IFNAR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P48551-1. | |||
TMPY-02634 |
IFNAR1 Protein, Human, Recombinant (hFc)
interferon (α, β and Ω) receptor 1,IFNBR,AVP,IFN-α-... |
Human | HEK293 Cells |
IFNAR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74 kDa and the accession number is P17181-1. | |||
TMPJ-00331 |
IFNAR1 Protein, Rhesus macaque, Recombinant (His)
IFN-al,CRF2-1,IFN-alpha/beta receptor 1,human i... |
Rhesus | HEK293 Cells |
Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory... | |||
TMPY-03758 |
Vaccinia Virus B18R/B19R Protein (His)
|
VACV | Baculovirus Insect Cells |
B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to un... | |||
TMPJ-00780 |
IFN-alpha 6/IFNA6 Protein, Human, Recombinant (His)
Interferon α-K,Interferon α-6,IFN α6,I... |
Human | HEK293 Cells |
Interferon α-6 (IFN-α6) is a secreted protein which belongs to the α/β interferon family. IFN-α6 is produced by macrophages, expressed at low level, only 1.0% of the average gene in this release. IFN-α6 contains interferon alpha, beta and delta domain. IFN-α has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. | |||
TMPY-02516 |
Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)
interferon, α10,interferon, alpha 10,IFN-a... |
Human | HEK293 Cells |
Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogen... | |||
TMPJ-00495 |
ISG15 Protein, Human, Recombinant (His)
ISG15,Ubiquitin Cross-Reactive Protein,G1P2,Interferon |
Human | E. coli |
Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermed... | |||
TMPH-02878 |
PTPRS Protein, Mouse, Recombinant (His & Myc)
|
Mouse | E. coli |
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteo... | |||
TMPH-03732 |
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
|
ZEBOV | E. coli |
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... | |||
TMPU-00003 |
STAT2 Protein, Human, Recombinant (His)
|
Human | E. coli |
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of... | |||
TMPH-03733 |
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
|
ZEBOV | HEK293 Cells |
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... | |||
TMPY-03610 |
PSME2 Protein, Human, Recombinant (His)
REGβ,proteasome (prosome, macropain) activator subunit 2 (PA... |
Human | E. coli |
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPY-03612 |
PSME1 Protein, Human, Recombinant (His)
proteasome (prosome, macropain) activator subunit 1 (PA28 al... |
Human | E. coli |
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunit... | |||
TMPY-04478 |
IP6K1/IHPK1 Protein, Human, Recombinant (His & GST)
inositol hexakisphosphate kinase 1,IHPK1,PiUS |
Human | Baculovirus Insect Cells |
IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. IHPK1 is an inositol hexaphosphate kinase (IHPK) protein that belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth-suppressive and... | |||
TMPJ-01056 |
IL-18 Protein, Mouse, Recombinant (His)
Interferon γ-inducing factor,Interleukin-1 gamma,Ig... |
Mouse | E. coli |
Interleukin-18 (IL-18)is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins... | |||
TMPY-02122 |
IFNGR2 Protein, Mouse, Recombinant (His)
interferon γ receptor 2 (interferon γ tran... |
Mouse | HEK293 Cells |
Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex al... | |||
TMPH-01552 |
IRF1 Protein, Human, Recombinant (GST & His)
|
Human | Baculovirus Insect Cells |
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm... | |||
TMPH-02632 |
TRIM21 Protein, Mouse, Recombinant (E. coli, His)
|
Mouse | E. coli |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... | |||
TMPH-02633 |
TRIM21 Protein, Mouse, Recombinant (His)
|
Mouse | Baculovirus Insect Cells |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr... |